Description

2-(3,5-Difluorophenyl)Piperidine Hydrochloride is a high-purity, fluorinated piperidine derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and scale-up of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and library synthesis.
• Active Pharmaceutical Ingredient (API) Development: Integral to the synthetic route of potential APIs, especially those requiring a difluorophenyl-piperidine pharmacophore.
• CNS Drug Discovery: Applied in the research of compounds for neurological and psychiatric disorders.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological targets and mechanisms.
• Process Chemistry & Scale-Up: Sourced for process optimization and pilot-scale manufacturing of developmental drugs.

Basic Information

Product Name	2-(3,5-Difluorophenyl)Piperidine Hydrochloride
CAS No.	1203685-51-1
Molecular Formula	C11H14ClF2N
Molecular Weight	233.69 g/mol
Synonyms	2-(3,5-Difluorophenyl)piperidine hydrochloride; 2-(3,5-Difluorophenyl)piperidine HCl; 3,5-Difluoro-2-piperidin-2-ylbenzene hydrochloride; Piperidine, 2-(3,5-difluorophenyl)-, hydrochloride; 1-(3,5-Difluorophenyl)-2-piperidine hydrochloride; 1203685-51-1; 2-(3,5-Difluorophenyl)piperidine monohydrochloride
EINECS	Contact for details

Quality Control

Our 2-(3,5-Difluorophenyl)Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with customer specifications and relevant industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.