Description

1-(2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridin-6-Yl)Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure protected by a tert-butyldimethylsilyl (TBDMS) group. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a key intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing under GMP conditions.
• Organic Synthesis Building Block: The protected hydroxyl group and acetyl functionality allow for selective further derivatization, making it valuable for constructing complex heterocyclic libraries.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of proprietary compounds for clinical trials.

Basic Information

Item	Detail
Product Name	1-(2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridin-6-Yl)Ethanone
CAS No.	1203499-37-9
Molecular Formula	C16H23NO3Si
Molecular Weight	305.45 g/mol
Synonyms	1-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxymethyl]furo[3,2-b]pyridin-6-yl]ethanone; 6-Acetyl-2-(((tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine; TBDMS-protected furopyridinyl ethanone; 6-Acetyl-2-((tert-butyldimethylsilyloxymethyl)furo[3,2-b]pyridine; 1-(2-(((tert-Butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridin-6-yl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 1-(2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridin-6-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with every shipment. We support development under quality standards appropriate for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment or under inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.