Description

(R)-3-(4-(2-(4-((S)-3-Chloro-2-Hydroxypropoxy)Phenyl)Propan-2-Yl)Phenoxy)Propane-1,2-Diol is a high-purity, advanced pharmaceutical intermediate with a complex chiral structure. Its primary value lies in its role as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical purity. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries. The material is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of proprietary drug candidates and complex target molecules.
• API Development: Used in research and process chemistry for developing new active pharmaceutical ingredients, especially those targeting G-protein-coupled receptors (GPCRs).
• Asymmetric Synthesis: Serves as a sophisticated chiral synthon for constructing molecules with specific three-dimensional configurations.
• Medicinal Chemistry Research: A valuable tool compound for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals where precise stereochemistry is required.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	(R)-3-(4-(2-(4-((S)-3-Chloro-2-Hydroxypropoxy)Phenyl)Propan-2-Yl)Phenoxy)Propane-1,2-Diol
CAS No.	1203490-23-6
Molecular Formula	C21H27ClO5
Molecular Weight	394.89 g/mol
Synonyms	(R)-3-[4-[2-[4-[(S)-3-Chloro-2-hydroxypropoxy]phenyl]propan-2-yl]phenoxy]propane-1,2-diol; 1,2-Propanediol, 3-[4-[2-[4-[(1S)-3-chloro-2-hydroxypropoxy]phenyl]-2-propanyl]phenoxy]-, (2R)-; UNII-7K3S3Y4W0F; 7K3S3Y4W0F; (2R)-3-{4-[2-(4-{(2S)-3-Chloro-2-hydroxypropoxy}phenyl)propan-2-yl]phenoxy}propane-1,2-diol; BMS intermediate derivative; Chiral bisphenol A glycidyl ether derivative
EINECS	Contact for details

Quality Control

Every batch of (R)-3-(4-(2-(4-((S)-3-Chloro-2-Hydroxypropoxy)Phenyl)Propan-2-Yl)Phenoxy)Propane-1,2-Diol is manufactured under strict quality management systems and undergoes comprehensive analytical testing. Our standard quality commitment includes HPLC purity ≥98.0% (typically >99.0%) and stringent control of enantiomeric excess (ee) to meet the demands of chiral synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. Specifications can be developed in alignment with ICH guidelines and customer-specific requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccant packs or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.