Description

trans-1-Aza-Spiro[4.5]Decan-8-Ol is a specialized spirocyclic amine alcohol building block of significant interest in advanced organic synthesis. This compound matters for its unique three-dimensional structure, which is highly valuable for constructing complex molecular architectures with potential for enhanced biological activity and selectivity. Pharmaceutical and agrochemical R&D teams need it as a key chiral intermediate in the development of novel active ingredients, particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A critical chiral scaffold in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its spirocyclic structure can contribute to novel modes of action.
• Ligand Synthesis: Serves as a precursor for sophisticated ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and receptor interactions.
• Advanced Material Science: A building block for functional polymers and dendrimers with specific optical or electronic properties.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	trans-1-Aza-Spiro[4.5]Decan-8-Ol
CAS No.	1202072-50-1
Molecular Formula	C9H17NO
Molecular Weight	155.24 g/mol
Synonyms	8-Hydroxy-1-azaspiro[4.5]decane (trans-); trans-8-Hydroxy-1-azaspiro[4.5]decane; 1-Azaspiro[4.5]decan-8-ol, (8R,9S)-rel-; Spiro[4.5]decan-8-ol, 1-aza-, trans-; Azaspirodecanol; Building Block 1202072-50-1; CAS 1202072-50-1
EINECS	Contact for details

Quality Control

Our trans-1-Aza-Spiro[4.5]Decan-8-Ol is produced under strict quality management systems to ensure batch-to-batch consistency for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral analysis to confirm stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant physical data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.