Description

4-Chloro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinoline is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the precise and efficient construction of complex quinoline-based molecular architectures, which are pivotal in advanced material and pharmaceutical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those targeting kinases and other therapeutic proteins.
• Agrochemical Research: Used to construct complex heterocyclic scaffolds for developing new generation herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Serves as a building block for creating organic semiconductors, light-emitting diodes (OLEDs), and other electronic materials due to the quinoline core's electron-transport properties.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorescent probes and molecular tags for imaging and diagnostic applications.
• Catalyst Ligand Synthesis: Utilized to develop novel bidentate or tridentate ligands for transition metal catalysis.
• Academic & Contract Research: A fundamental reagent for methodological development and exploring new synthetic pathways in university and CRO laboratories.

Basic Information

Product Name	4-Chloro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinoline
CAS No.	1201844-73-6
Molecular Formula	C₁₇H₂₁BClNO₂
Molecular Weight	317.62 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-chloroquinoline; 4-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline; Quinoline, 4-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-Chloro-6-(pinacolatoboron)quinoline; 4-Chloro-6-quinolineboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinoline undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. Our quality assurance protocols are designed to guarantee reliable performance in sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to maintain stability. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or ambient temperature will compromise quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.