Description

(S)-1-(2,5-Difluorophenyl)Ethanamine Hydrochloride CAS NO 1201363-81-6 is a high-purity chiral amine hydrochloride salt, a critical building block in modern organic synthesis. Its value lies in providing a stereochemically defined, fluorinated aromatic scaffold essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas where fluorine substitution modulates potency and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in developing advanced crop protection agents and pesticides, where the difluorophenyl moiety can enhance bioactivity and environmental persistence.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science: Employed in the synthesis of specialty polymers and advanced organic materials that require fluorinated aromatic components for specific electronic or physical properties.
• Chemical Biology & Proteomics: Utilized as a tagged molecular probe or a building block for activity-based protein profiling (ABPP) to study enzyme function.

Basic Information

Product Name	(S)-1-(2,5-Difluorophenyl)Ethanamine Hydrochloride
CAS No.	1201363-81-6
Molecular Formula	C8H10ClF2N
Molecular Weight	193.62 g/mol
Synonyms	(S)-1-(2,5-Difluorophenyl)ethan-1-amine hydrochloride; (S)-α-Methyl-2,5-difluorobenzylamine hydrochloride; (1S)-1-(2,5-Difluorophenyl)ethylamine hydrochloride; (S)-(-)-1-(2,5-Difluorophenyl)ethylamine HCl; (S)-2,5-Difluoro-α-methylbenzylamine hydrochloride; (S)-1-(2,5-Difluorophenyl)ethylammonium chloride
EINECS	Contact for details

Quality Control

Our (S)-1-(2,5-Difluorophenyl)Ethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.