Description

Atabecestat CAS NO 1200493-78-2 is a potent and selective small-molecule inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1), a key target in Alzheimer's disease research. Its development represents a significant effort to modulate amyloid-beta peptide production, a central pathological hallmark of the condition. This high-purity compound is essential for pharmaceutical R&D, specifically for preclinical studies, mechanism of action investigations, and as a critical reference standard in analytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for quality control and analytical method validation (HPLC, LC-MS) in drug development pipelines.
• Preclinical Neuroscience Research: Used in in vitro and in vivo studies to investigate BACE1 inhibition, amyloid-beta pathology, and potential therapeutic efficacy for Alzheimer's disease.
• Biochemical Assay Development: Employed as a key reagent in high-throughput screening (HTS) campaigns and enzymatic assays to discover and characterize novel BACE1 inhibitors.
• Mechanism of Action Studies: Critical for elucidating the structure-activity relationship (SAR) of BACE1 inhibitors and understanding drug-target interactions.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and process development of potential therapeutic candidates targeting BACE1.

Basic Information

Product Name	Atabecestat
CAS No.	1200493-78-2
Molecular Formula	C23H21F3N4O3
Molecular Weight	458.44 g/mol
Synonyms	JNJ-54861911; JNJ 54861911; JNJ54861911; (3S)-3-[4-(Difluoromethoxy)phenyl]-1-[(4-fluorophenyl)methyl]-5-[(5-methyl-1,2-oxazol-3-yl)methoxy]-2,4-imidazolidinedione
EINECS	Contact for details

Quality Control

Our Atabecestat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS are provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.