Description

3-Amino-6-Aza-Bicyclo[3.2.1]Octane-6-Carboxylic Acid tert-Butyl Ester is a sophisticated bicyclic amino acid derivative, serving as a critical protected intermediate in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in pharmaceutical research where its rigid scaffold and protected functional groups are invaluable. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas requiring constrained peptidomimetics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce a rigid, three-dimensional bicyclic amino acid motif into peptide backbones.
• Peptidomimetic Synthesis: Essential for creating conformationally restricted peptide analogs that enhance metabolic stability, bioavailability, and receptor selectivity.
• Chemical Biology Probes: Employed in the development of specialized probes and tool compounds for studying enzyme mechanisms and protein-protein interactions.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scalable synthesis of complex target molecules under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Utilized in universities and research institutes for methodological development in organic synthesis and the exploration of new chemical space.

Basic Information

Product Name	3-Amino-6-Aza-Bicyclo[3.2.1]Octane-6-Carboxylic Acid tert-Butyl Ester
CAS No.	1199942-73-8
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	tert-Butyl 3-amino-6-azabicyclo[3.2.1]octane-6-carboxylate; 6-(tert-Butoxycarbonyl)-3-amino-6-azabicyclo[3.2.1]octane; 3-Amino-6-Boc-6-azabicyclo[3.2.1]octane; 6-Azabicyclo[3.2.1]octane-6-carboxylic acid, 3-amino-, 1,1-dimethylethyl ester; 3-Amino-6-N-Boc-6-azabicyclo[3.2.1]octane; Bicyclic amino acid tert-butyl ester; 6-Aza-3-aminobicyclo[3.2.1]octane-6-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-Amino-6-Aza-Bicyclo[3.2.1]Octane-6-Carboxylic Acid tert-Butyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports research and development requiring reliable, high-purity advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.