Description

1-(4-Bromophenyl)-3-Hydroxycyclobutanecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclobutane carboxylic acid core substituted with a bromophenyl group. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating compounds with potential therapeutic activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or metabolic diseases.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile functional groups for further chemical modification.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, or plant growth regulators that utilize halogenated aromatic motifs.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and other advanced intermediates.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for exploratory synthetic chemistry and method development projects.

Basic Information

Product Name	1-(4-Bromophenyl)-3-Hydroxycyclobutanecarboxylic Acid
CAS No.	1199556-64-3
Molecular Formula	C11H11BrO3
Molecular Weight	271.11 g/mol
Synonyms	3-Hydroxy-1-(4-bromophenyl)cyclobutanecarboxylic acid; 1-(4-Bromophenyl)-3-hydroxycyclobutanecarboxylic acid; 4-Bromo-α-(3-hydroxycyclobutyl)benzenecarboxylic acid; Cyclobutanecarboxylic acid, 1-(4-bromophenyl)-3-hydroxy-; (3-Hydroxycyclobutyl)(4-bromophenyl)carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-(4-Bromophenyl)-3-Hydroxycyclobutanecarboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.