Description

2-(2-Fluorophenyl)Pyrrolidine Hydrochloride is a high-purity fluorinated pyrrolidine derivative, a key building block in modern pharmaceutical and agrochemical research. Its value lies in its role as a versatile chiral intermediate for constructing complex molecules with enhanced biological activity and metabolic stability. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorophenyl moiety can improve lipophilicity and target binding.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or a tagging reagent in probe development for studying biological systems.
• Material Science: Investigated as a monomer or additive for creating specialty polymers with unique optical or electronic properties.
• Academic & Contract Research: A valuable reagent for methodological studies in organic synthesis and medicinal chemistry within university and CRO laboratories.

Basic Information

Product Name	2-(2-Fluorophenyl)Pyrrolidine Hydrochloride
CAS No.	1197227-16-9
Molecular Formula	C10H13FN • HCl
Molecular Weight	201.68 g/mol (Free base: 165.22 g/mol)
Synonyms	2-(2-Fluorophenyl)pyrrolidine HCl; 2-(2-Fluorophenyl)pyrrolidine hydrochloride; 1-(2-Fluorophenyl)pyrrolidine-2-hydrochloride (common misnomer); 2-(o-Fluorophenyl)pyrrolidine hydrochloride; Pyrrolidine, 2-(2-fluorophenyl)-, hydrochloride (1:1); 1197227-16-9; FC-0663 (potential research code); AS-102395 (potential vendor code)
EINECS	Contact for details

Quality Control

Our 2-(2-Fluorophenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR and IR for structural confirmation, and KF titration for water content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.