Description

6-(Trifluoromethyl)Isoquinolin-1-Amine is a specialized heterocyclic aromatic amine building block featuring a trifluoromethyl substituent. This compound is valued for its unique structural motif, which combines the isoquinoline scaffold with the electron-withdrawing and lipophilicity-enhancing properties of the trifluoromethyl group. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinases, GPCRs, and other biological receptors.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for the development of advanced organic materials, such as ligands for catalysis or components for organic electronic devices.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	6-(Trifluoromethyl)Isoquinolin-1-Amine
CAS No.	1196157-31-9
Molecular Formula	C10H7F3N2
Molecular Weight	212.17 g/mol
Synonyms	1-Amino-6-(trifluoromethyl)isoquinoline; 6-(Trifluoromethyl)-1-isoquinolinamine; 6-Trifluoromethylisoquinolin-1-ylamine; 1-Isoquinolinamine, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)-1-aminoisoquinoline
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Isoquinolin-1-Amine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.