Description

6-Bromo-8-Fluoro-3,4-Dihydroquinolin-2(1H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated quinolinone core structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Organic Synthesis Building Block: Serves as a versatile precursor for further functionalization via cross-coupling reactions, nucleophilic substitutions, and other transformations.
• Agrochemical Research: Potential intermediate in the development of new herbicides or fungicides, leveraging its halogenated heterocyclic structure.
• Material Science Applications: Investigated as a precursor for organic electronic materials due to its fused aromatic system.

Basic Information

Product Name	6-Bromo-8-Fluoro-3,4-Dihydroquinolin-2(1H)-One
CAS No.	1194459-25-0
Molecular Formula	C9H7BrFNO
Molecular Weight	244.06 g/mol
Synonyms	6-Bromo-8-fluoro-1,2,3,4-tetrahydroquinolin-2-one; 6-Bromo-8-fluoro-3,4-dihydro-2(1H)-quinolinone; 8-Fluoro-6-bromo-3,4-dihydroquinolin-2(1H)-one; 2(1H)-Quinolinone, 6-bromo-8-fluoro-3,4-dihydro-; 6-Bromo-8-fluoro-1,2,3,4-tetrahydro-2-quinolone
EINECS	Contact for details

Quality Control

Our 6-Bromo-8-Fluoro-3,4-Dihydroquinolin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.