Description

4-(2,2,2-Trifluoroethoxy)Butan-1-Amine Hydrochloride is a high-purity organic building block featuring a unique trifluoroethoxy side chain, which imparts significant lipophilicity and metabolic stability to target molecules. This compound is essential for medicinal chemistry research and development, particularly in the synthesis of novel pharmaceutical candidates. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex amine intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the trifluoroethoxy group can enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or catalysts used in asymmetric synthesis.
• Fluorinated Compound Research: A valuable building block for introducing fluorine-containing motifs into molecules to alter their physicochemical properties.
• Peptidomimetics and Bio-conjugates: Employed in the design of peptide analogs and bioconjugation linkers for drug delivery systems.
• Material Science: Potential monomer or modifier in the synthesis of specialty polymers with unique surface properties.

Basic Information

Product Name	4-(2,2,2-Trifluoroethoxy)Butan-1-Amine Hydrochloride
CAS No.	1193389-27-3
Molecular Formula	C6H13ClF3NO
Molecular Weight	207.62 g/mol
Synonyms	4-(2,2,2-Trifluoroethoxy)butylamine hydrochloride; 1-Amino-4-(2,2,2-trifluoroethoxy)butane hydrochloride; 4-(Trifluoroethoxy)butan-1-amine HCl; Butan-1-amine, 4-(2,2,2-trifluoroethoxy)-, hydrochloride; 4-(2,2,2-Trifluoroethoxy)butylammonium chloride
EINECS	Contact for details

Quality Control

Every batch of 4-(2,2,2-Trifluoroethoxy)Butan-1-Amine Hydrochloride is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.