Description

4-(Trifluoromethyl)Piperidin-4-Ol Hydrochloride is a high-purity, synthetically valuable trifluoromethylated piperidine derivative. This compound is a crucial pharmaceutical intermediate and building block for medicinal chemistry research, enabling the introduction of the metabolically stable trifluoromethyl group into target molecules. It is primarily sought by R&D and process development teams in the pharmaceutical, agrochemical, and advanced material sectors for the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization programs to explore structure-activity relationships (SAR) by incorporating the trifluoromethyl group.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Advanced Material Precursor: Potential monomer or additive for specialty polymers and functional materials requiring fluorine-containing moieties.
• Chemical Biology Probes: Used to create tool compounds for studying biological targets and pathways.

Basic Information

Product Name	4-(Trifluoromethyl)Piperidin-4-Ol Hydrochloride
CAS No.	1193389-14-8
Molecular Formula	C7H13ClF3NO
Molecular Weight	219.63 g/mol
Synonyms	4-(Trifluoromethyl)-4-piperidinol hydrochloride; 4-Hydroxy-4-(trifluoromethyl)piperidine hydrochloride; 4-Piperidinol, 4-(trifluoromethyl)-, hydrochloride; 4-Trifluoromethyl-4-hydroxypiperidine HCl; 4-(Trifluoromethyl)piperidin-4-ol HCl; 4-Hydroxy-α,α,α-trifluoro-1-piperidinepropanenitrile hydrochloride (incorrect but sometimes listed); α,α,α-Trifluoro-4-piperidinol hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Piperidin-4-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.