Description

(4-Bromophenyl)(Cyclobutyl)Methanamine Hydrochloride is a high-purity organic building block and pharmaceutical intermediate. This compound is valued for its unique structural motif, which incorporates both a brominated aromatic ring and a cyclobutyl group, making it a versatile synthon for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors. The hydrochloride salt form offers enhanced stability and handling properties for synthetic applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its bromine handle for further functionalization via cross-coupling reactions.
• Agrochemical Synthesis: Acts as a precursor in the development of new herbicides, fungicides, and insecticides that require specific aryl-alkyl amine backbones.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological targets and pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	(4-Bromophenyl)(Cyclobutyl)Methanamine Hydrochloride
CAS No.	1193387-95-9
Molecular Formula	C11H14BrN·HCl
Molecular Weight	276.60 g/mol
Synonyms	1-(4-Bromophenyl)-1-cyclobutylmethanamine hydrochloride; (4-Bromophenyl)(cyclobutyl)methanamine HCl; α-Cyclobutyl-4-bromobenzylamine hydrochloride; 4-Bromo-α-cyclobutylbenzenemethanamine hydrochloride; N-(4-Bromobenzyl)cyclobutanamine hydrochloride; (Cyclobutyl)(4-bromophenyl)methylamine hydrochloride; 4-Bromophenyl cyclobutyl methylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (4-Bromophenyl)(Cyclobutyl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for advanced pharmaceutical applications, ensuring traceability and regulatory compliance for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original packaging to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.