Description

4-[(2,2,2-Trifluoroethoxy)Methyl]Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core modified with a trifluoroethoxymethyl group. This compound is of significant value in modern medicinal chemistry, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) agents, receptor modulators, and other therapeutic candidates where the introduction of fluorine-containing motifs is advantageous.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• API Synthesis: Incorporated into the final synthetic steps for the production of fluorinated active pharmaceutical ingredients.
• Biochemical Tool Compound: Serves as a ligand or probe in biochemical assays and pharmacological studies targeting specific receptors or enzymes.
• Agrochemical Research: Potential application as an intermediate in the development of advanced, fluorinated agrochemicals.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, complex fluorinated building blocks.

Basic Information

Product Name	4-[(2,2,2-Trifluoroethoxy)Methyl]Piperidine Hydrochloride
CAS No.	1193387-27-7
Molecular Formula	C9H16ClF3NO
Molecular Weight	246.68 g/mol
Synonyms	4-[(2,2,2-Trifluoroethoxy)methyl]piperidine HCl; 1-(2,2,2-Trifluoroethoxymethyl)piperidin-4-amine hydrochloride; 4-(Trifluoroethoxymethyl)piperidine hydrochloride; Piperidine, 4-[(2,2,2-trifluoroethoxy)methyl]-, hydrochloride; 1193387-27-7; 4-(2,2,2-Trifluoroethoxymethyl)piperidine HCl salt
EINECS	Contact for details

Quality Control

Our 4-[(2,2,2-Trifluoroethoxy)Methyl]Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.