Description

3-Iodoazetidine Hydrochloride is a high-value, functionalized azetidine building block used in advanced organic synthesis. This compound is particularly significant for its role in medicinal chemistry and drug discovery, where the strained four-membered azetidine ring and iodine handle enable the construction of novel bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, chemical probes, and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor for synthesizing novel drug candidates, particularly in fragment-based drug design and lead optimization.
• Medicinal Chemistry Research: Used to introduce the azetidine scaffold, a privileged structure known to improve pharmacokinetic properties like metabolic stability and solubility.
• Chemical Biology: Serves as a versatile building block for creating chemical probes and tool compounds to study biological pathways and protein function.
• Agrochemical Synthesis: Employed in the research and development of new pesticides and herbicides that incorporate heterocyclic motifs.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse compound libraries.
• Academic Research: Used in universities and institutes for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-Iodoazetidine Hydrochloride
CAS No.	1193386-43-4
Molecular Formula	C3H7ClIN
Molecular Weight	219.45 g/mol
Synonyms	Azetidine, 3-iodo-, hydrochloride (1:1); 3-Iodoazetidine HCl; 3-Iodo-azetidine hydrochloride; Azetidine, 3-iodo-, monohydrochloride; 3-Iodoazetidinium chloride
EINECS	Contact for details

Quality Control

Our 3-Iodoazetidine Hydrochloride is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.