Description

{n-[3-(N6-Phenyl)Propyl]-[(1R-2R)-1,2-Diphenyl-1-4-Methylbenzenesulfonylamidato(Kn')-Ethyl-2-Amino-(Kn)]}Ruthenium(II) (R,R)-Teth-Tsdpen RuCl, commonly known as the Wills Catalyst, is a highly specialized chiral ruthenium complex designed for asymmetric hydrogenation and transfer hydrogenation reactions. This catalyst is critical for achieving high enantioselectivity in the synthesis of chiral amines and alcohols, which are key intermediates in pharmaceutical and fine chemical manufacturing. It is an essential tool for R&D and production chemists in industries requiring precise stereochemical control.

Application

• Asymmetric Synthesis of Pharmaceutical Intermediates: Key for producing enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.
• Chiral Amine Production: Enantioselective hydrogenation of imines and enamines to yield valuable chiral amine building blocks.
• Transfer Hydrogenation Reactions: Utilized in reactions using hydrogen donors like formic acid or isopropanol for ketone and imine reduction.
• Fine Chemical and Agrochemical Synthesis: Manufacture of chiral ligands, flavors, fragrances, and agrochemicals with high optical purity.
• Academic and Industrial R&D: A benchmark catalyst for developing new asymmetric catalytic processes and methodologies.
• Process Chemistry Optimization: Scaling up enantioselective transformations from laboratory to pilot plant and commercial production.

Basic Information

Item	Details
Product Name	{n-[3-(N6-Phenyl)Propyl]-[(1R-2R)-1,2-Diphenyl-1-4-Methylbenzenesulfonylamidato(Kn')-Ethyl-2-Amino-(Kn)]}Ruthenium(II) (R,R)-Teth-Tsdpen RuCl Wills Catalyst
CAS No.	1192620-83-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R,R)-Wills Catalyst; (R,R)-TsDPEN Ru Catalyst; (R,R)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine Ruthenium Chloride Complex; (R,R)-Ru-TsDPEN; Chiral Ruthenium TsDPEN Catalyst; Asymmetric Hydrogenation Catalyst RuCl[(R,R)-TsDPEN]; (R,R)-Teth-Tsdpen RuCl; Ruthenium(II) (R,R)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine Chloride
EINECS	Contact for details

Quality Control

Our (R,R)-Wills Catalyst is produced under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including chiral purity (enantiomeric excess) verification, ruthenium content assay, and identification by spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C. This compound is moisture-sensitive (hygroscopic) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Assay (Ruthenium Content)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (e.g., DCM, THF, methanol)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.