Description

cis-tert-Butyl 3-Aminocyclobutanecarboxylate Hydrochloride is a high-purity, protected amino acid derivative salt, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized cyclobutane scaffold essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, peptide mimetics, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in protease inhibitor and constrained peptide analog programs.
• Medicinal Chemistry: Used to introduce the constrained cyclobutane ring system into lead compounds to modulate potency, selectivity, and metabolic stability.
• Peptidomimetics: Serves as a backbone-constrained, protected amino acid unit for the synthesis of peptide mimics with enhanced bioavailability.
• Agrochemical Research: Employed in the synthesis of novel, biologically active molecules for crop protection and pest management.
• Chemical Biology: Useful as a molecular probe or a building block for labeled compounds in biochemical and pharmacological studies.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and asymmetric catalysis within academic and CRO laboratories.

Basic Information

Item	Detail
Product Name	cis-tert-Butyl 3-Aminocyclobutanecarboxylate Hydrochloride
CAS No.	1192549-09-9
Molecular Formula	C9H18ClNO2
Molecular Weight	207.70 g/mol
Synonyms	1,1-Dimethylethyl (1r,3s)-3-aminocyclobutanecarboxylate hydrochloride; cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid hydrochloride; cis-Boc-3-aminocyclobutanecarboxylic acid tert-butyl ester hydrochloride; (1r,3s)-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid tert-butyl ester hydrochloride; cis-tert-Butyl 3-((tert-butoxycarbonyl)amino)cyclobutanecarboxylate hydrochloride (protected form); cis-3-Aminocyclobutanecarboxylic acid tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our cis-tert-Butyl 3-Aminocyclobutanecarboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.