Description

Tricyclohexylphosphine[1,3-Bis(2,4,6-Trimethylphenyl)Imidazol-2-Ylidene] [2-Thienylmethylene]Ruthenium(Ii) Dichloride, Min. 95% is a highly specialized, second-generation Grubbs-Hoveyda type ruthenium-based olefin metathesis catalyst. This compound matters for its exceptional thermal stability and functional group tolerance, enabling precise and efficient carbon-carbon double bond formation in complex molecular architectures. It is critically needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing active ingredients, novel polymers, and fine chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for ring-closing metathesis (RCM), cross metathesis (CM), and ring-opening metathesis polymerization (ROMP) in the production of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used to construct novel heterocyclic and macrocyclic frameworks for new herbicides, fungicides, and insecticides with improved efficacy.
• Advanced Polymer & Material Science: Enables the synthesis of specialty polymers, functionalized materials, and self-healing composites via precise ROMP and CM reactions.
• Fine Chemical & Specialty Chemical Production: Facilitates the efficient, scalable synthesis of fragrance compounds, flavors, and other high-value fine chemicals requiring selective olefin transformations.
• Academic & Industrial R&D: An essential tool for methodology development and exploring new synthetic routes in organic chemistry laboratories worldwide.
• Process Chemistry Optimization: Valued for its robustness in flow chemistry and continuous manufacturing setups for more sustainable chemical production.

Basic Information

Product Name	Tricyclohexylphosphine[1,3-Bis(2,4,6-Trimethylphenyl)Imidazol-2-Ylidene] [2-Thienylmethylene]Ruthenium(Ii) Dichloride, Min. 95%
CAS No.	1190427-49-6
Molecular Formula	C46H60Cl2N2PRuS
Molecular Weight	888.98 g/mol
Synonyms	Grubbs-Hoveyda II Catalyst; Hoveyda-Grubbs Catalyst 2nd Generation; (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium (with PCy3); Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene][(2-thienylmethylene)](tricyclohexylphosphine)ruthenium(II); HG II; RuCl2(IMesH2)(CH-2-Thienyl)(PCy3); [Ru]=CH(2-Thienyl) Catalyst
EINECS	Contact for details

Quality Control

Every batch of our ruthenium metathesis catalysts is produced and tested under strict inert atmosphere conditions to prevent decomposition. We employ advanced analytical techniques including NMR, HPLC, and elemental analysis to verify identity, purity, and catalytic activity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is both hygroscopic (moisture-sensitive) and easily oxidized; exposure to air, moisture, or elevated temperatures will lead to rapid degradation and loss of catalytic activity. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	Min. 95%
Elemental Analysis (C, H, N)	Within theoretical ± 0.4%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.