Description

(5S)-6,7-Dihydro-5H-Pyrrolo[1,2-B][1,2,4]Triazole-5-Methanol CAS NO 1190392-80-3 is a high-purity chiral building block and advanced pharmaceutical intermediate characterized by its fused pyrrolotriazole structure. This compound is of significant value for its role in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, where its defined stereochemistry and functional group are critical for achieving desired pharmacological profiles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral targets.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to introduce complexity and chirality into target molecules.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for candidate drugs during clinical development phases.
• Bioconjugation & Probe Development: The hydroxymethyl group can be functionalized for use in creating chemical probes or for bioconjugation applications in chemical biology.

Basic Information

Product Name	(5S)-6,7-Dihydro-5H-Pyrrolo[1,2-B][1,2,4]Triazole-5-Methanol
CAS No.	1190392-80-3
Molecular Formula	C7H9N3O
Molecular Weight	151.17 g/mol
Synonyms	(5S)-5H-Pyrrolo[1,2-b][1,2,4]triazole-5-methanol, 6,7-dihydro-; (5S)-6,7-Dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-5-ylmethanol; (S)-6,7-Dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole-5-methanol; (S)-5-(Hydroxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole; Chiral Pyrrolotriazole Methanol; (5S)-Pyrrolotriazole Methanol Derivative
EINECS	Contact for details

Quality Control

Our (5S)-6,7-Dihydro-5H-Pyrrolo[1,2-B][1,2,4]Triazole-5-Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high-purity standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, assay, chiral purity, and impurity profile is supplied with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.