Description

5-Methoxy-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one is a high-value, fluorinated indolinone derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique molecular architecture, featuring a methoxy group and a trifluoromethyl substituent on the indole core, makes it indispensable for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Material Science Precursor: Employed in the research of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its electron-deficient aromatic system.
• Chemical Biology Probe: Serves as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for client projects.

Basic Information

Product Name	5-Methoxy-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one
CAS No.	1190198-26-5
Molecular Formula	C10H8F3NO2
Molecular Weight	231.17 g/mol
Synonyms	5-Methoxy-6-(trifluoromethyl)indolin-2-one; 2H-Indol-2-one, 1,3-dihydro-5-methoxy-6-(trifluoromethyl)-; 6-(Trifluoromethyl)-5-methoxyindolin-2-one; 5-Methoxy-6-trifluoromethyl-2-indolinone; CAS 1190198-26-5; Fluorinated indolinone intermediate
EINECS	Contact for details

Quality Control

Our production of 5-Methoxy-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one adheres to stringent in-process controls and final release testing protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.