Description

Methyl 4-(Trifluoromethyl)Pyrrolidine-3-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrolidine scaffold and trifluoromethyl group. This compound is of significant commercial interest for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and metabolic disorder therapeutics. It is primarily utilized by research institutions, custom synthesis organizations, and pharmaceutical companies engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex molecules targeting neurological and psychiatric disorders.
• Drug Discovery & Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies due to its privileged pyrrolidine structure.
• Process Research & Development (R&D): Serves as a critical starting material or intermediate in scaling up API synthesis routes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of candidate drugs.
• Agrochemical Research: Potential application as an intermediate in the development of novel crop protection agents with fluorinated motifs.
• Academic & Industrial Research: Employed in chemical biology and as a reagent for exploring new synthetic methodologies involving fluorinated heterocycles.

Basic Information

Product Name	Methyl 4-(Trifluoromethyl)Pyrrolidine-3-Carboxylate Hydrochloride
CAS No.	1189909-25-8
Molecular Formula	C8H11F3NO2 • HCl
Molecular Weight	249.63 g/mol (Free base: 210.17 g/mol)
Synonyms	Methyl 4-(trifluoromethyl)-3-pyrrolidinecarboxylate hydrochloride; 3-Pyrrolidinecarboxylic acid, 4-(trifluoromethyl)-, methyl ester, hydrochloride; Methyl 4-(trifluoromethyl)pyrrolidine-3-carboxylate HCl; 4-(Trifluoromethyl)pyrrolidine-3-carboxylic acid methyl ester hydrochloride; 1189909-25-8
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-(Trifluoromethyl)Pyrrolidine-3-Carboxylate Hydrochloride is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical-grade material meets the stringent requirements for advanced intermediate use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.