Description

p-Fluoro Fentanyl-D3 is a stable isotope-labeled analog of the synthetic opioid fentanyl, specifically deuterated at three positions. This compound is an essential reference standard and internal standard for precise analytical quantification in forensic, clinical, and pharmaceutical research. It is primarily utilized by analytical laboratories, forensic toxicologists, and pharmaceutical R&D departments engaged in method development and validation. The deuterium labeling provides a reliable mass spectrometric signature, enabling accurate detection and measurement of its non-labeled counterpart in complex biological matrices.

Application

• Analytical Reference Standard: Serves as a certified reference material (CRM) for calibrating analytical instruments like LC-MS/MS and GC-MS in forensic and clinical toxicology.
• Internal Standard for Quantitation: Used as a deuterated internal standard to ensure accuracy and precision in the quantitative analysis of fentanyl and its analogs in biological samples (e.g., blood, urine, tissue).
• Metabolic and Pharmacokinetic Studies: Facilitates research into the absorption, distribution, metabolism, and excretion (ADME) profiles of fentanyl-related compounds.
• Forensic Analysis and Drug Testing: Critical for the identification and confirmation of illicit fentanyl analogs in law enforcement and workplace drug testing programs.
• Pharmaceutical Impurity Profiling: Aids in the detection and characterization of potential genotoxic impurities or degradation products in pharmaceutical formulations.
• Research on Opioid Receptor Binding: Employed in biochemical assays to study the binding affinity and selectivity of novel opioid receptor ligands.

Basic Information

Product Name	p-Fluoro Fentanyl-D3
CAS No.	1189887-65-7
Molecular Formula	C₂₂H₂₅D₃FN₂O
Molecular Weight	352.50 g/mol
Synonyms	N-Phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide-3,3,3-d3, 4'-Fluorofentanyl-D3; 4-Fluorofentanyl-D3; para-Fluorofentanyl-D3; Fentanyl-3,3,3-d3, 4'-fluoro-; 1-Phenethyl-4-(N-(3,3,3-trideuteriopropanoyl)anilino)piperidine, 4'-fluoro-
EINECS	Contact for details

Quality Control

Our p-Fluoro Fentanyl-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic purity (D3), and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting batch-specific data for critical parameters. We ensure compliance with relevant standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.