Description

n-Nitrososarcosine-D3 is a stable isotope-labeled analog of n-nitrososarcosine, where three hydrogen atoms are replaced by deuterium. This compound is of significant value as a high-purity internal standard and reference material for precise analytical quantification in research and regulatory testing. It is essential for laboratories in the pharmaceutical, food safety, and environmental monitoring sectors requiring accurate trace analysis of nitrosamine impurities, a critical quality and safety parameter.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the accurate quantification of n-nitrososarcosine and related nitrosamines via liquid chromatography-tandem mass spectrometry.
• Pharmaceutical Impurity Testing: Critical reference material for method development and validation in detecting and monitoring nitrosamine genotoxic impurities (GTIs) in active pharmaceutical ingredients (APIs) and drug products to comply with FDA, EMA, and ICH M7 guidelines.
• Food and Beverage Safety Analysis: Used in analytical methods to test for nitrosamine contamination in processed foods, cured meats, and alcoholic beverages.
• Environmental and Toxicological Research: Serves as a stable isotope tracer in metabolic fate studies, environmental monitoring, and research into the formation and toxicity of N-nitroso compounds.
• Method Development and Validation: Provides a reliable benchmark for developing, calibrating, and verifying analytical procedures in contract research organizations (CROs) and quality control laboratories.
• Regulatory Compliance and Certification: Supports testing protocols for regulatory submissions and safety certifications, ensuring data integrity and meeting global pharmacopeial standards.

Basic Information

Product Name	n-Nitrososarcosine-D3
CAS No.	1189871-94-0
Molecular Formula	C5H6D3N3O3
Molecular Weight	150.15 g/mol
Synonyms	N-Nitrososarcosine-d3; Sarcosine, N-nitroso-, methyl-d3-; Deuterated N-Nitrososarcosine; N-Methyl-N-nitroso-d3-glycine; N-Nitroso-N-(methyl-d3)glycine; Nitrososarcosine-methyl-d3; [2H3]-N-Nitrososarcosine; N-Nitrososarcosine (methyl-d3)
EINECS	Contact for details

Quality Control

Every batch of n-Nitrososarcosine-D3 is manufactured and analyzed under strict quality management systems to ensure the high purity and isotopic enrichment required for analytical standards. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for isotopic purity, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. For long-term stability, consider storage at 2-8°C. Keep the container tightly sealed in a well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.