Description

4-Bromo-5,8-Difluoro-2-Phenylquinoline is a high-purity, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is valued for its unique halogenated and fluorinated quinoline structure, which provides critical reactivity and electronic properties for creating complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and other biologically active heterocycles.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and pesticides, leveraging the fluorine and bromine substituents for enhanced bioactivity and environmental stability.
• Material Science Precursor: Serves as a monomer or functional unit in the synthesis of advanced organic electronic materials, such as OLEDs, organic semiconductors, and liquid crystals.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and other metal-catalyzed transformations due to the reactive bromine atom.
• Fluorinated Compound Library Synthesis: An essential scaffold for medicinal chemistry and combinatorial chemistry to build diverse libraries of fluorinated compounds for high-throughput screening.

Basic Information

Product Name	4-Bromo-5,8-Difluoro-2-Phenylquinoline
CAS No.	1189107-68-3
Molecular Formula	C15H8BrF2N
Molecular Weight	320.14 g/mol
Synonyms	4-Bromo-5,8-difluoro-2-phenylquinoline; 2-Phenyl-4-bromo-5,8-difluoroquinoline; 4-Bromo-5,8-difluoro-2-phenyl-quinoline; Quinoline, 4-bromo-5,8-difluoro-2-phenyl-; 1189107-68-3; 4-Br-5,8-F2-2-Ph-quinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-5,8-Difluoro-2-Phenylquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.