Description

4-Bromo-2-Phenyl-8-Trifluoromethoxyquinoline is a high-value, multi-functional heterocyclic building block. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), particularly those targeting specific biological pathways. Pharmaceutical researchers, agrochemical developers, and material scientists need this precise chemical scaffold to create novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to develop new generations of pesticides and herbicides with improved efficacy and selectivity.
• Material Science: Serves as a building block for organic light-emitting diodes (OLEDs) and other advanced electronic materials due to its quinoline core and halogen/trifluoromethoxy substituents.
• Chemical Synthesis: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex molecular architectures.
• Ligand & Catalyst Development: Utilized in the design of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Probe Synthesis: The quinoline structure makes it suitable for developing fluorescent markers and sensors for biological imaging.

Basic Information

Product Name	4-Bromo-2-Phenyl-8-Trifluoromethoxyquinoline
CAS No.	1189107-67-2
Molecular Formula	C₁₇H₁₀BrF₃NO
Molecular Weight	381.17 g/mol
Synonyms	4-Bromo-2-phenyl-8-(trifluoromethoxy)quinoline; 8-Trifluoromethoxy-4-bromo-2-phenylquinoline; 2-Phenyl-4-bromo-8-trifluoromethoxyquinoline; Quinoline, 4-bromo-2-phenyl-8-(trifluoromethoxy)-; 1189107-67-2; 4-Br-2-Ph-8-OCF3-Quinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Phenyl-8-Trifluoromethoxyquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and tendency to be easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.