Description

4-Chloro-2-Phenyl-8-Trifluoromethoxyquinoline is a high-value, multi-functional quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring chloro, phenyl, and trifluoromethoxy substituents, makes it an essential intermediate for developing novel compounds with tailored properties. This product is primarily targeted at research and development teams in the pharmaceutical, agrochemical, and materials science industries seeking to create new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for applications in oncology, anti-infectives, and central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of next-generation pesticides and herbicides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Material Science: Serves as a monomer or functional additive in the creation of advanced polymers, liquid crystals, and organic electronic materials (OLEDs, OFETs).
• Chemical Synthesis: Acts as a versatile scaffold for further functionalization via cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations in medicinal and process chemistry.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental research into heterocyclic chemistry and structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Chloro-2-Phenyl-8-Trifluoromethoxyquinoline
CAS No.	1189106-99-7
Molecular Formula	C₁₇H₁₀ClF₃NO
Molecular Weight	348.72 g/mol
Synonyms	4-Chloro-2-phenyl-8-(trifluoromethoxy)quinoline; 8-Trifluoromethoxy-4-chloro-2-phenylquinoline; 2-Phenyl-4-chloro-8-trifluoromethoxyquinoline; 4-Chloro-2-phenyl-8-(trifluoromethoxy)quinoline; Quinoline, 4-chloro-2-phenyl-8-(trifluoromethoxy)-; 1189106-99-7
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Phenyl-8-Trifluoromethoxyquinoline is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity specifications suitable for research and development applications. Certificates of Analysis (COA) detailing lot-specific results from HPLC, NMR, and MS are provided with each shipment. Custom synthesis and purification to meet specific project requirements (e.g., >99% HPLC purity) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.