Description

4-Chloro-2-Phenyl-6-Trifluoromethoxyquinoline is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters because its unique molecular architecture, featuring chloro, phenyl, and trifluoromethoxy substituents, provides critical structural motifs for modulating the biological activity and physicochemical properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly in medicinal chemistry programs targeting kinase inhibition and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides, where the trifluoromethoxy group can enhance metabolic stability and lipophilicity.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as charge-transport layers or light-emitting components, due to its conjugated quinoline core.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental studies in organic chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	4-Chloro-2-Phenyl-6-Trifluoromethoxyquinoline
CAS No.	1189106-94-2
Molecular Formula	C₁₇H₉ClF₃NO
Molecular Weight	335.71 g/mol
Synonyms	4-Chloro-2-phenyl-6-(trifluoromethoxy)quinoline; 6-(Trifluoromethoxy)-4-chloro-2-phenylquinoline; 2-Phenyl-4-chloro-6-trifluoromethoxyquinoline; 4-Chloro-2-phenyl-6-trifluoromethoxy-quinoline; Quinoline, 4-chloro-2-phenyl-6-(trifluoromethoxy)-; 1189106-94-2
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Phenyl-6-Trifluoromethoxyquinoline is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.