Description

4-Bromo-6,8-Difluoro-2-Methylquinoline is a high-purity, multi-functional halogenated quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique bromo- and difluoro-substituted quinoline structure makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antimicrobial research programs.
• Agrochemical Synthesis: Used in the creation of advanced fungicides and herbicides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor for electron-transporting or host materials in display and lighting technologies.
• Ligand and Catalyst Development: The quinoline nitrogen provides a coordination site for metal complexes used in catalysis.
• Fluorescent Probe and Dye Chemistry: The core structure can be modified to create sensors and imaging agents for biochemical applications.
• Academic and Contract Research: Employed in methodological studies and discovery chemistry within university and CRO laboratories.

Basic Information

Product Name	4-Bromo-6,8-Difluoro-2-Methylquinoline
CAS No.	1189106-86-2
Molecular Formula	C₁₀H₆BrF₂N
Molecular Weight	258.06 g/mol
Synonyms	4-Bromo-6,8-difluoro-2-methylquinoline; 2-Methyl-4-bromo-6,8-difluoroquinoline; 6,8-Difluoro-4-bromo-2-methylquinoline; Quinoline, 4-bromo-6,8-difluoro-2-methyl-; 1189106-86-2; 4-Bromo-6,8-difluoro-2-methyl-quinoline
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-6,8-Difluoro-2-Methylquinoline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.