Description

4-Bromo-5,8-Difluoro-2-Propylquinoline is a high-value, multi-functional halogenated quinoline derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its precise molecular architecture, featuring bromine and fluorine substituents, makes it indispensable for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of next-generation pesticides and herbicides, where the difluoro and bromo groups contribute to enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers, organic semiconductors, and liquid crystals.
• Chemical Synthesis Scaffold: A versatile intermediate for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and further functionalization to create diverse quinoline-based compound libraries.
• Fluorescent Probe Development: Potential use as a core structure for synthesizing fluorescent dyes and sensors used in biochemical assays and diagnostics.

Basic Information

Product Name	4-Bromo-5,8-Difluoro-2-Propylquinoline
CAS No.	1189106-85-1
Molecular Formula	C₁₂H₁₀BrF₂N
Molecular Weight	286.12 g/mol
Synonyms	4-Bromo-5,8-difluoro-2-propylquinoline; 2-Propyl-4-bromo-5,8-difluoroquinoline; Quinoline, 4-bromo-5,8-difluoro-2-propyl-; 1189106-85-1; 4-Bromo-5,8-difluoro-2-n-propylquinoline
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-5,8-Difluoro-2-Propylquinoline is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.