Description

4-Bromo-7,8-Difluoro-2-Methylquinoline is a high-purity, multi-functional halogenated quinoline derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its precise molecular architecture, featuring bromine and fluorine substituents, makes it an indispensable building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other therapeutic agents.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging the bioactivity of the quinoline core.
• Material Science: Serves as a precursor for organic electronic materials, including ligands for OLEDs and other optoelectronic devices.
• Chemical Synthesis: An essential building block for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the quinoline moiety into more complex structures.
• Fluorinated Compound Libraries: Integral for creating focused libraries of fluorinated compounds in drug discovery, where fluorine atoms are used to modulate pharmacokinetics.

Basic Information

Product Name	4-Bromo-7,8-Difluoro-2-Methylquinoline
CAS No.	1189106-60-2
Molecular Formula	C10H6BrF2N
Molecular Weight	258.06 g/mol
Synonyms	4-Bromo-7,8-difluoro-2-methylquinoline; 2-Methyl-4-bromo-7,8-difluoroquinoline; 7,8-Difluoro-4-bromo-2-methylquinoline; Quinoline, 4-bromo-7,8-difluoro-2-methyl-; 1189106-60-2
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-7,8-Difluoro-2-Methylquinoline is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.