Description

4-Amino-7,8-Difluoro-2-Phenylquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinoline scaffold with strategic fluorine and amino substitutions. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced potency and metabolic stability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of targeted therapies, particularly in oncology and anti-infective research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) and investigational new drugs.
• Fluorinated Quinoline Synthesis: Serves as a core scaffold for creating libraries of fluorinated quinoline derivatives for structure-activity relationship (SAR) studies.
• Kinase Inhibitor Research: Used in the development of potential kinase inhibitors due to the quinoline structure's affinity for ATP-binding sites.
• Antimicrobial Agent Development: Explored as a building block for novel antibacterial and antifungal agents, leveraging the bioactivity of the quinoline core.
• Chemical Biology Probes: Utilized in the design of fluorescent probes or photoaffinity labels for studying biological targets and pathways.
• Material Science Research: Investigated as an organic component for advanced materials, such as organic semiconductors or metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Amino-7,8-Difluoro-2-Phenylquinoline
CAS No.	1189106-49-7
Molecular Formula	C15H10F2N2
Molecular Weight	256.25 g/mol
Synonyms	2-Phenyl-7,8-difluoroquinolin-4-amine; 4-Amino-7,8-difluoro-2-phenylquinoline; 7,8-Difluoro-2-phenyl-4-quinolinamine; 4-Quinolinamine, 7,8-difluoro-2-phenyl-; 1189106-49-7; 4-Amino-7,8-difluoro-2-phenyl-quinoline; 2-Phenyl-7,8-difluoro-4-aminoquinoline
EINECS	Contact for details

Quality Control

Our 4-Amino-7,8-Difluoro-2-Phenylquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.