Description

4-Chloro-7,8-Difluoro-2-Phenylquinoline is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core quinoline scaffold, strategically substituted with chlorine and fluorine atoms, provides a versatile platform for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science: Serves as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and other functional organic electronic materials due to its rigid, conjugated structure.
• Chemical Synthesis: Acts as a versatile ligand in catalysis and a scaffold for creating complex heterocyclic libraries for high-throughput screening in drug discovery.
• Fluorinated Compound Synthesis: The difluoro motif makes it a valuable starting material for introducing fluorine into target molecules, a common strategy in modern medicinal chemistry.

Basic Information

Product Name	4-Chloro-7,8-Difluoro-2-Phenylquinoline
CAS No.	1189106-42-0
Molecular Formula	C15H8ClF2N
Molecular Weight	275.68 g/mol
Synonyms	4-Chloro-7,8-difluoro-2-phenylquinoline; 2-Phenyl-4-chloro-7,8-difluoroquinoline; 7,8-Difluoro-4-chloro-2-phenylquinoline; 4-Chloro-2-phenyl-7,8-difluoroquinoline; Quinoline, 4-chloro-7,8-difluoro-2-phenyl-; 1189106-42-0; 4-Cl-7,8-F2-2-Ph-quinoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-7,8-Difluoro-2-Phenylquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO standards ensures reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.