Description

4-Bromo-5,8-Difluoroquinoline is a high-purity, multi-functional halogenated quinoline derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique structure, featuring bromine and fluorine substituents at strategic positions, makes it an exceptionally valuable building block for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other therapeutic agents.
• Agrochemical Research: Used to develop novel fungicides, herbicides, and pesticides, leveraging the bioactivity of the quinoline core enhanced by halogen atoms.
• Material Science: Serves as a building block for creating organic semiconductors, light-emitting diodes (OLEDs), and other electronic materials due to its conjugated system.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a versatile scaffold for further functionalization in organic chemistry R&D.
• Ligand & Catalyst Development: Utilized in the design of novel ligands for metal catalysis and coordination chemistry applications.
• Fluorescent Probe Synthesis: Acts as a core structure for developing sensitive fluorescent dyes and probes used in biochemical assays and diagnostics.

Basic Information

Product Name	4-Bromo-5,8-Difluoroquinoline
CAS No.	1189106-41-9
Molecular Formula	C9H4BrF2N
Molecular Weight	244.04 g/mol
Synonyms	4-Bromo-5,8-difluoroquinoline; 5,8-Difluoro-4-bromoquinoline; Quinoline, 4-bromo-5,8-difluoro-; 1189106-41-9; 4-Bromo-5,8-difluoro-quinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-5,8-Difluoroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards required for research and development applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.