Description

4-Amino-2-Propyl-8-Trifluoromethylquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinoline scaffold substituted with amino, propyl, and trifluoromethyl groups. This compound matters for its critical role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular frameworks. Pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers need this intermediate to develop next-generation compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, antiviral, and anti-inflammatory research.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the quinoline core and fluorine atoms can contribute to bioactivity and environmental persistence.
• Material Science Precursor: Serves as a starting material for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Ligand Synthesis: Acts as a precursor for creating complex ligands used in catalysis and coordination chemistry.
• Fluorinated Compound Library: An essential component for combinatorial chemistry and high-throughput screening to discover new fluorinated bioactive molecules.

Basic Information

Product Name	4-Amino-2-Propyl-8-Trifluoromethylquinoline
CAS No.	1189106-38-4
Molecular Formula	C₁₃H₁₃F₃N₂
Molecular Weight	254.25 g/mol
Synonyms	8-Trifluoromethyl-4-amino-2-propylquinoline; 2-Propyl-8-(trifluoromethyl)quinolin-4-amine; 4-Amino-2-propyl-8-(trifluoromethyl)quinoline; 4-Amino-2-propyl-8-trifluoromethylquinoline; 8-Trifluoromethyl-2-propylquinolin-4-amine; Quinoline, 4-amino-2-propyl-8-(trifluoromethyl)-; 1189106-38-4
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Propyl-8-Trifluoromethylquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.