Description

Ethyl 4,7-Dichloroquinazoline-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its quinazoline core structure. This compound is a critical building block in the synthesis of targeted small molecule drugs, particularly kinase inhibitors used in oncology research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing who require reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazoline-based kinase inhibitors for cancer therapy.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry Development: Serves as a defined starting material for scaling up the production of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis: A versatile substrate for further functionalization to create specialized libraries of compounds for screening.

Basic Information

Product Name	Ethyl 4,7-Dichloroquinazoline-2-Carboxylate
CAS No.	1189106-09-9
Molecular Formula	C11H8Cl2N2O2
Molecular Weight	271.10 g/mol
Synonyms	Ethyl 4,7-dichloro-2-quinazolinecarboxylate; 4,7-Dichloroquinazoline-2-carboxylic acid ethyl ester; 2-Quinazolinecarboxylic acid, 4,7-dichloro-, ethyl ester; Ethyl 4,7-dichloroquinazoline-2-carboxylate; 1189106-09-9
EINECS	Contact for details

Quality Control

Our Ethyl 4,7-Dichloroquinazoline-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.