Description

5-Iodo-2,3-Dihydrobenzo[B][1,4]Dioxine is a high-purity, halogenated benzodioxine derivative serving as a critical synthetic intermediate in advanced organic chemistry. This compound is valued for its unique molecular scaffold, which enables the construction of complex heterocyclic systems and facilitates key coupling reactions in pharmaceutical and materials science research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that require a halogenated benzodioxine core.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed reactions such as Suzuki, Sonogashira, and Heck couplings for carbon-carbon bond formation.
• Ligand Synthesis: Utilized for creating novel chelating ligands in catalysis and metal-organic framework (MOF) construction.
• Fluorescent Probe Development: Acts as a core structure for synthesizing iodine-labeled probes and tags used in bioimaging and diagnostic assays.

Basic Information

Product Name	5-Iodo-2,3-Dihydrobenzo[B][1,4]Dioxine
CAS No.	1188265-13-5
Molecular Formula	C8H7IO2
Molecular Weight	262.05 g/mol
Synonyms	5-Iodobenzo-1,4-dioxane; 5-Iodo-1,4-benzodioxane; 5-Iodo-2,3-dihydro-1,4-benzodioxin; 1,4-Benzodioxine, 5-iodo-2,3-dihydro-; Benzo[1,4]dioxine, 5-iodo-2,3-dihydro-; 5-Iodo-2,3-dihydrobenzo-1,4-dioxine
EINECS	Contact for details

Quality Control

Every batch of 5-Iodo-2,3-Dihydrobenzo[B][1,4]Dioxine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent in-house specifications developed for research and industrial use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.