Description

1-Boc-4-Methylaminopiperidine-Hcl is a high-purity, protected piperidine derivative widely used as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemists and process development scientists seeking to introduce a methylamino-piperidine moiety into target molecules with high selectivity and yield. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs), particularly within the pharmaceutical and agrochemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in scaffold hopping and structure-activity relationship (SAR) studies to optimize pharmacokinetic and pharmacodynamic properties.
• Process Chemistry & Scale-up: Serves as a reliable starting material for the kilogram-scale production of advanced intermediates under GMP conditions.
• Agrochemical Synthesis: Employed in the development of novel herbicides and fungicides that require specific amine functionalities.
• Peptide Mimetics & PROTACs: Integral for constructing complex molecules such as peptide analogs and proteolysis-targeting chimeras (PROTACs).
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein function.

Basic Information

Product Name	1-Boc-4-Methylaminopiperidine-Hcl
CAS No.	1188263-65-1
Molecular Formula	C11H23ClN2O2
Molecular Weight	250.77 g/mol
Synonyms	1-Boc-4-(Methylamino)piperidine hydrochloride; tert-Butyl 4-(methylamino)piperidine-1-carboxylate hydrochloride; 4-(Methylamino)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride; N-Boc-4-methylaminopiperidine HCl; 1-(tert-Butoxycarbonyl)-4-methylaminopiperidine hydrochloride; 4-Methylamino-piperidine-1-carboxylic acid tert-butyl ester hydrochloride; Boc-4-MAP-HCl; 1-Boc-4-MAP-HCl
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Methylaminopiperidine-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.