Description

1-Bromo-4-Fluoro-2,3-Dihydro-1H-Indene is a high-value, multi-functional halogenated indane derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on a partially saturated indene core, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile scaffold for Suzuki-Miyaura and other cross-coupling reactions, enabling rapid exploration of chemical space in discovery chemistry.
• Ligand and Catalyst Development: Utilized to create novel phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	1-Bromo-4-Fluoro-2,3-Dihydro-1H-Indene
CAS No.	1188171-96-1
Molecular Formula	C9H8BrF
Molecular Weight	215.06 g/mol
Synonyms	4-Fluoro-1-bromo-2,3-dihydro-1H-indene; 1-Bromo-4-fluoroindane; 1H-Indene, 1-bromo-4-fluoro-2,3-dihydro-; 4-Fluoro-1-bromoindane; 1-Bromo-4-fluoro-2,3-dihydroindene; 1188171-96-1; 4-Fluoroindan-1-yl bromide
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-4-Fluoro-2,3-Dihydro-1H-Indene is manufactured and tested under strict quality management systems to ensure batch-to-batch consistency and high purity. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep away from strong bases and fluorides. The container must be kept tightly closed and stored in a dry atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.