Description

2-Chloro-5,7-Difluoroquinoline is a high-value, multi-functional halogenated quinoline derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and material science sectors for developing novel active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used as a core scaffold for developing new-generation herbicides, fungicides, and pesticides with enhanced efficacy.
• Material Science Research: Serves as a building block for creating organic light-emitting diodes (OLEDs), liquid crystals, and other functional organic materials.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Fluorescent Probe Synthesis: The quinoline core, when functionalized, is valuable for creating sensitive fluorescent dyes and biological imaging agents.
• Academic and Contract Research: Essential for medicinal chemistry programs and discovery research in university and CRO (Contract Research Organization) laboratories.

Basic Information

Item	Detail
Product Name	2-Chloro-5,7-Difluoroquinoline
CAS No.	1188002-20-1
Molecular Formula	C9H4ClF2N
Molecular Weight	199.59 g/mol
Synonyms	5,7-Difluoro-2-chloroquinoline; 2-Chloro-5,7-difluoroquinoline; Quinoline, 2-chloro-5,7-difluoro-; 1188002-20-1; 2-Chloro-5,7-difluoro-quinoline
EINECS	Contact for details

Quality Control

We maintain a strict quality management system to ensure batch-to-batch consistency and high purity. Our 2-Chloro-5,7-Difluoroquinoline is produced under controlled conditions and undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We can support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.