Description

8-Bromo-4,4-Dimethyl-1,2,3,4-Tetrahydroquinoline is a high-value, synthetically versatile brominated heterocyclic building block. This compound is essential for advanced organic synthesis, particularly in the construction of complex molecular architectures for pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for applications in medicinal chemistry, including the development of new active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Scaffold: Used for structure-activity relationship (SAR) studies and library synthesis due to its modifiable bromine substituent and rigid tetrahydroquinoline core.
• Agrochemical Research: Serves as a building block for developing new pesticides and herbicides with potential novel modes of action.
• Material Science: Can be utilized in the synthesis of organic electronic materials and advanced functional polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations.
• Ligand Synthesis: Potential starting material for creating novel nitrogen-containing ligands for catalysis.

Basic Information

Product Name	8-Bromo-4,4-Dimethyl-1,2,3,4-Tetrahydroquinoline
CAS No.	1187933-50-1
Molecular Formula	C11H14BrN
Molecular Weight	240.14 g/mol
Synonyms	8-Bromo-4,4-dimethyl-1,2,3,4-tetrahydroquinoline; 4,4-Dimethyl-8-bromo-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-8-bromo-4,4-dimethylquinoline; 8-Bromo-4,4-dimethyl-3,4-dihydro-2H-quinoline; 8-Bromo-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline; Quinoline, 8-bromo-1,2,3,4-tetrahydro-4,4-dimethyl-
EINECS	Contact for details

Quality Control

Our 8-Bromo-4,4-Dimethyl-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports your research and development needs with reliable, high-purity intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.