Description

8-Fluoro-4,4-Dimethyl-1,3-Dihydroquinolin-2-One is a high-purity, synthetically valuable fluorinated heterocyclic building block. This compound is essential for advanced pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate its unique fluorinated quinolinone scaffold.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used as a building block for developing novel pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a starting material for synthesizing specialized organic ligands, fluorophores, or advanced polymers with tailored electronic properties.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting fundamental research in organic and medicinal chemistry.

Basic Information

Product Name	8-Fluoro-4,4-Dimethyl-1,3-Dihydroquinolin-2-One
CAS No.	1187933-46-5
Molecular Formula	C₁₁H₁₀FNO
Molecular Weight	191.20 g/mol
Synonyms	8-Fluoro-4,4-dimethyl-1,2-dihydroquinolin-2-one; 8-Fluoro-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one; 2(1H)-Quinolinone, 8-fluoro-4,4-dimethyl-1,3-dihydro-; 8-Fluoro-4,4-dimethyl-1,3-dihydro-2H-quinolin-2-one; 4,4-Dimethyl-8-fluoro-1,3-dihydroquinolin-2-one; 8-Fluoro-4,4-dimethyl-1,2-dihydro-2-quinolone
EINECS	Contact for details

Quality Control

Our 8-Fluoro-4,4-Dimethyl-1,3-Dihydroquinolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.