Description

8-Bromo-4,4-Dimethyl-3,4-Dihydroquinolin-2(1H)-One is a high-purity, synthetically valuable brominated quinolinone derivative. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis, enabling the construction of complex molecular architectures. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Organic Synthesis Building Block: The bromine atom provides a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Heck) to create diverse chemical libraries.
• Material Science Precursor: Employed in the research of organic electronic materials, such as charge-transport molecules or luminescent compounds.
• Chemical Biology Probe: Utilized in medicinal chemistry to study protein-ligand interactions and enzyme inhibition mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production for clinical trials.

Basic Information

Item	Detail
Product Name	8-Bromo-4,4-Dimethyl-3,4-Dihydroquinolin-2(1H)-One
CAS No.	1187933-36-3
Molecular Formula	C11H12BrNO
Molecular Weight	254.13 g/mol
Synonyms	8-Bromo-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-2-one; 8-Bromo-4,4-dimethyl-3,4-dihydro-2(1H)-quinolinone; 4,4-Dimethyl-8-bromo-1,2,3,4-tetrahydroquinolin-2-one; 8-Bromo-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-2-one; 8-Bromo-4,4-dimethyl-2-oxo-1,2,3,4-tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our 8-Bromo-4,4-Dimethyl-3,4-Dihydroquinolin-2(1H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.