Description

(R)-3-Amino-3,4-Dihydro-2H-Quinoline-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research and production in pharmaceutical development, particularly for creating novel therapeutic agents in oncology, neurology, and other specialized fields.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to introduce the (R)-configured amino-dihydroquinoline moiety into target molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Fine Chemical Production: Employed in the manufacture of high-value specialty chemicals, catalysts, and ligands for organic synthesis.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up and cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	(R)-3-Amino-3,4-Dihydro-2H-Quinoline-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1187933-31-8
Molecular Formula	C14H18N2O2
Molecular Weight	246.31 g/mol
Synonyms	(R)-1-Boc-3-amino-1,2,3,4-tetrahydroquinoline; tert-Butyl (R)-3-amino-3,4-dihydro-2H-quinoline-1-carboxylate; (R)-3-Amino-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; (R)-1-N-Boc-3-amino-1,2,3,4-tetrahydroquinoline; (R)-3-Amino-N-Boc-1,2,3,4-tetrahydroquinoline; (R)-Boc-3-ATQ; (R)-Boc-3-Amino-THQ
EINECS	Contact for details

Quality Control

Our (R)-3-Amino-3,4-Dihydro-2H-Quinoline-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification methods, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.