Description

(S)-1-Boc-3,4-Dihydro-2H-Quinoline-2-Carboxylic Acid is a high-purity, enantiomerically pure chiral building block of significant importance in advanced organic synthesis. Its core value lies in providing a protected, stereodefined quinoline scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is critically needed by research and development teams in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals where stereochemistry is a key determinant of biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate for constructing complex, enantiomerically pure molecules via various coupling and cyclization reactions.
• Peptidomimetics & Bioactive Molecule Design: Used to incorporate a rigid, fused bicyclic structure into peptide backbones or other bioactive scaffolds to modulate conformation and potency.
• Agrochemical Research: Employed in the synthesis of novel, stereospecific herbicides, fungicides, or plant growth regulators.
• Catalyst & Ligand Development: Can be utilized as a precursor for developing novel chiral catalysts or ligands used in asymmetric catalysis.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic chemistry and for scaling up synthetic routes in process development.

Basic Information

Product Name	(S)-1-Boc-3,4-Dihydro-2H-Quinoline-2-Carboxylic Acid
CAS No.	1187933-14-7
Molecular Formula	C₁₆H₁₉NO₄
Molecular Weight	289.33 g/mol
Synonyms	(2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-2H-quinoline-2-carboxylic acid; (S)-1-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; (S)-N-Boc-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; (S)-1-Boc-THQ-2-COOH; (S)-1-Boc-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; (S)-2-Carboxy-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; BOC-(S)-1,2,3,4-Tetrahydroquinoline-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-3,4-Dihydro-2H-Quinoline-2-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including HPLC for chemical purity and chiral HPLC or polarimetry for enantiomeric excess (ee). Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.