Description

8-Bromo-1,4,4-Trimethyl-1,2,3,4-Tetrahydroquinoline is a high-purity brominated tetrahydroquinoline derivative, a crucial advanced intermediate in modern organic synthesis. Its value lies in its unique halogenated heterocyclic structure, which serves as a versatile building block for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where it is used to introduce the bromine moiety for further functionalization or as a core scaffold.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides, leveraging the bioactivity of the quinoline core.
• Material Science Research: Serves as a precursor for the synthesis of functional organic materials, such as ligands for catalysts or components in organic electronics.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological processes due to its modifiable bromine handle.
• Academic & R&D Laboratories: Employed in methodological studies and as a standard in cross-coupling reactions like Suzuki or Buchwald-Hartwig amination.

Basic Information

Product Name	8-Bromo-1,4,4-Trimethyl-1,2,3,4-Tetrahydroquinoline
CAS No.	1187932-52-0
Molecular Formula	C₁₂H₁₆BrN
Molecular Weight	254.17 g/mol
Synonyms	8-Bromo-1,4,4-trimethyl-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-8-bromo-1,4,4-trimethylquinoline; Quinoline, 8-bromo-1,2,3,4-tetrahydro-1,4,4-trimethyl-; 8-Bromo-1,4,4-trimethyl-3,4-dihydro-1H-quinoline; 8-Bromo-1,4,4-trimethyl-1,2,3,4-tetrahydro-quinoline
EINECS	Contact for details

Quality Control

Our 8-Bromo-1,4,4-Trimethyl-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with your specifications. Our quality commitment supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.