Description

Exo-1-Aza-Bicyclo[2.2.1]Hept-3-Ylamine Dihydrochloride is a high-purity, bicyclic amine hydrochloride salt of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and a versatile intermediate for the development of novel pharmaceutical agents and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral scaffold for the synthesis of potential drug candidates targeting neurological and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Asymmetric Synthesis: Employed as a chiral amine source or auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-donor ligands used in transition metal catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme function.
• Process Chemistry: Investigated for scalable synthetic routes in the development of Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Exo-1-Aza-Bicyclo[2.2.1]Hept-3-Ylamine Dihydrochloride
CAS No.	1187932-51-9
Molecular Formula	C6H13Cl2N
Molecular Weight	170.08 g/mol
Synonyms	Exo-3-Aminonortropane Dihydrochloride; (1R,2S,3S,4S)-3-Aminobicyclo[2.2.1]heptane-2-carboxylic Acid Dihydrochloride (related); 3-exo-Aminonortropane Dihydrochloride; 1-Azabicyclo[2.2.1]heptan-3-amine, dihydrochloride, (1R,2S,3S,4S)-rel-; Bicyclo[2.2.1]heptan-3-amine, 1-aza-, dihydrochloride, exo-; Nortropan-3-amine Dihydrochloride, exo-
EINECS	Contact for details

Quality Control

Our Exo-1-Aza-Bicyclo[2.2.1]Hept-3-Ylamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.