Description

8-Bromo-1,4,4-Trimethyl-3,4-Dihydro-1H-Quinolin-2-One is a high-purity brominated quinolinone derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its heterocyclic core structure.
• Chemical Biology Probe Development: Serves as a precursor for creating molecular probes to study enzyme function and biological pathways.
• Material Science: Potential intermediate in the synthesis of organic electronic materials or specialty polymers with unique optical properties.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting exploratory synthetic chemistry.
• Custom Synthesis & Scale-Up: A starting point for custom manufacturing and process optimization for commercial-scale production of target molecules.

Basic Information

Product Name	8-Bromo-1,4,4-Trimethyl-3,4-Dihydro-1H-Quinolin-2-One
CAS No.	1187932-46-2
Molecular Formula	C₁₂H₁₄BrNO
Molecular Weight	268.15 g/mol
Synonyms	8-Bromo-1,4,4-trimethyl-3,4-dihydroquinolin-2(1H)-one; 8-Bromo-1,4,4-trimethyl-1,4-dihydroquinolin-2-one; 8-Bromo-1,4,4-trimethyl-1,2,3,4-tetrahydroquinolin-2-one; 8-Bromo-1,4,4-trimethyl-2-oxo-1,2,3,4-tetrahydroquinoline; 2(1H)-Quinolinone, 8-bromo-1,4,4-trimethyl-3,4-dihydro-; 8-Bromo-1,4,4-trimethyl-3,4-dihydro-2(1H)-quinolinone
EINECS	Contact for details

Quality Control

Our 8-Bromo-1,4,4-Trimethyl-3,4-Dihydro-1H-Quinolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including pharmaceutical R&D under GMP-like conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.