Description

tert-Butyl 7-Bromo-4,4-Dimethyl-3,4-Dihydroquinoline-1(2H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its brominated quinoline core protected by a tert-butoxycarbonyl (Boc) group. This compound is a critical building block in modern organic synthesis, enabling the efficient construction of complex nitrogen-containing heterocycles. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Organic Synthesis Building Block: Used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce functionalized quinoline scaffolds into larger molecular architectures.
• Agrochemical Research: Employed in the development of new herbicides and pesticides due to its bioactive quinoline structure.
• Material Science: Investigated as a monomer or precursor for the synthesis of specialty polymers and organic electronic materials.
• Academic & R&D: A valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	tert-Butyl 7-Bromo-4,4-Dimethyl-3,4-Dihydroquinoline-1(2H)-Carboxylate
CAS No.	1187932-35-9
Molecular Formula	C16H20BrNO2
Molecular Weight	338.24 g/mol
Synonyms	7-Bromo-1,2,3,4-tetrahydro-4,4-dimethylquinoline-1-carboxylic acid tert-butyl ester; 1-Boc-7-bromo-4,4-dimethyl-1,2,3,4-tetrahydroquinoline; tert-Butyl 7-bromo-4,4-dimethyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 7-Bromo-4,4-dimethyl-3,4-dihydro-1H-quinoline-1-carboxylic acid tert-butyl ester; BOC-7-Bromo-4,4-DMQ; 1187932-35-9
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 7-Bromo-4,4-Dimethyl-3,4-Dihydroquinoline-1(2H)-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and current industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. The container should be kept tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.